Supplements and brain aging

Is it possible, through adequate nutraceutical strategies, to adequately support brain physiology, promote maintenance of cognitive functions over time, reduce oxidative damage at the neuronal level and thus avoid pathological aging of our brain? This is an extremely relevant topic, especially with a view to preventing the onset of neurodegenerative diseases linked to aging, which in recent years have been increasing worryingly on a global level Noocube review.

Most cases of Alzheimer’s disease are sporadic, with multifactorial etiology, in which environmental and genetic differences can act as risk factors. The best known genetic risk factor is the inheritance of the ε4 allele of apolipoprotein E (APO-E). The APO-Eε4 allele increases the risk of the disease by approximately three times in heterozygotes and by 8-15 times in homozygotes. The most recent evidence, resulting from analyzes of population groups with genetic risk factors and from clinically normal subjects, suggests that the pathophysiological process of Alzheimer’s actually begins many years before the clinical diagnosis of cognitive impairment, Among the environmental variables, diet is certainly the one most able to influence our state of health and the quality of aging, and this also seems to be true for the brain.

Vitamins

In general, the brain is particularly sensitive to vitamin deficiencies: especially some B vitamins play a crucial role in maintaining brain physiology. Vitamin B6 helps modulate the synthesis of neurotransmitters such as serotonin and norepinephrine and is also involved in the formation of the sheath that lines the nerve fibers. Vitamin B12 intervenes in the regulation of neuronal functions and trophism and its deficiency causes loss of memory and concentration, mood disorders and dementia.